Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.
MouseIschaemia-reperfusionRenalC57BL/6JMaleOral, in the diet1.0 mmol/kg/day sodium nitrate in chowStarted 2 weeks before ischaemia and continued throughout the reperfusion period
Model: Unilateral renal ischaemia-reperfusion: left renal pedicle clamped with a micro serrefine (100 g clamping pressure) for 30 min, followed by 24 h or 2 weeks of reperfusion
Nitrate-supplemented chow reduced tubular and glomerular damage and preserved renal function after unilateral ischaemia-reperfusion, with plasma creatinine at 24 h falling from 1.03 to 0.79 ug/ml and glomerular filtration rate and renal plasma flow both improved at 2 weeks. Protection was accompani…
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