Remote ischemic conditioning preserves cognition and motor coordination in a mouse model of traumatic brain injury.
MouseTBIControlled cortical impactC57BLMalen = 100 male C57BL mice, 50 remote ischaemic conditioning and 5…Femoral artery clamping (remote hindlimb ischaemia)Six cycles of 4 min ischaemia and 4 min reperfusion induced…2 h after traumatic brain injury
Model: Closed-skull controlled cortical impact traumatic brain injury
Remote ischaemic conditioning gave a significantly higher recognition index at 24, 48 and 72 h and longer rotarod latency (significant at 120 h), with less neuronal degeneration and astrocytosis; systemic neuronal injury markers did not differ between groups.
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