THERAPY DOSSIER · th-756b2d571dcb

Remote ischaemic conditioning (RIC)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03899532 ↗Injury indicationNAwithdrawn

Effect of Remote Ischemic Conditioning on Inflammatory Biomarkers and Outcomes in TBI

Traumatic Brain Injury

Enrolment: 0 · Results not recorded

NCT06911385 ↗PHASE1/PHASE2not yet recruiting

Augmenting Cerebral Blood Flow Using Remote Ischemic Conditioning in Ischemic Stroke

Stroke

Enrolment: 150 · Results not recorded

NCT07270887 ↗NArecruiting

Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASCVD Patients (RICMO-ASCVD)

ASCVD

Enrolment: 2800 · Results not recorded

NCT02381522 ↗NAcompleted

Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage

Brain Aneurysms

Enrolment: 26 · Results not recorded

NCT06536231 ↗NArecruiting

Hemodynamic Variations During Remote Ischemic Conditioning in Critically Ill Patients

Critical Illness

Enrolment: 50 · Results not recorded

NCT07179887 ↗NArecruiting

Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation

Cerebral Autoregulation · Blood Pressure

Enrolment: 45 · Results not recorded

NCT07762547 ↗NAnot yet recruiting

Pharmacological and Physical Therapy (incl. RIC) in Delaying Progression of Moyamoya Disease

Moyamoya Disease

Enrolment: 724 · Results not recorded

NCT05225948 ↗NAunknown

Effects of Remote Ischemic Conditioning in Patients With Cerebral Small Vessel Disease

Cerebral Small Vessel Diseases

Enrolment: 100 · Results not recorded

NCT04805346 ↗NAcompleted

Remote Ischemic Conditioning for Protection from Cardiotoxicity in Pediatric Anthracycline Chemotherapy

Anthracycline Chemotherapy

Enrolment: 1 · Results not recorded

NCT02044471 ↗NAcompleted

IMPULSE Pilot: Ischemic Conditioning in Continuous-Flow LVAD Patients

Chronic Heart Failure

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28609381 ↗2017Reported benefit

Remote ischemic conditioning preserves cognition and motor coordination in a mouse model of traumatic brain injury.

MouseTBIControlled cortical impactC57BLMalen = 100 male C57BL mice, 50 remote ischaemic conditioning and 5…Femoral artery clamping (remote hindlimb ischaemia)Six cycles of 4 min ischaemia and 4 min reperfusion induced…2 h after traumatic brain injury

Model: Closed-skull controlled cortical impact traumatic brain injury

Remote ischaemic conditioning gave a significantly higher recognition index at 24, 48 and 72 h and longer rotarod latency (significant at 120 h), with less neuronal degeneration and astrocytosis; systemic neuronal injury markers did not differ between groups.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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