Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition.
MouseRadiationC57BL/6Femalen = 30 mice per group across four groups; 6 mice per group kill…Intraperitoneal injection100 mg/kg/dayStarted 3 days before irradiation and continued after irradiation; in vitro cel…
Model: Radiation-induced lung injury from a single 15 Gy whole-thorax irradiation (cobalt-60 source, 1 Gy/min), followed to 16 weeks; supporting in vitro work in BEAS-2B human bronchial epithelial cells irradiated at 8 Gy
Polydatin reduced pulmonary congestion, oedema and lung coefficient, lowered early inflammation and late collagen deposition and hydroxyproline, inhibited epithelial-mesenchymal transition and TGF-beta1-Smad3-Snail signalling, and corrected the Th1/Th2 cytokine shift. Radioprotection depended on Si…
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