Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)MaleIntracerebroventricular and intraperitoneal10 ug/kg body weight for the intraperitoneal route; intrace…
Model: Middle cerebral artery occlusion (45 min ischaemia followed by 24 h reperfusion), focal cerebral ischaemia/reperfusion
Resistin given by intracerebroventricular or intraperitoneal route reduced infarct volume and neurological deficits after MCAO, lowered PARP-1 cleavage and raised phospho-Akt, with improved balance and muscle strength at 14 days. Neuroprotection was partially reversed by wortmannin, implicating PI3…
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