THERAPY DOSSIER · th-9b9e6ae397ef

Resistin (recombinant adipokine peptide)

Biologic · ChEMBL not queried for this recombinant adipokine in this run. ClinicalTrials.gov searched: 38 raw hits, ALL measure resistin as a circulating biomarker (probiotic, bariatric, stroke-biomarker, hepatitis C and diabetic-foot studies); NONE administers resistin as an intervention. Zero relevant human trials recorded.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL not queried for this recombinant adipokine in this run. ClinicalTrials.gov searched: 38 raw hits, ALL measure resistin as a circulating biomarker (probiotic, bariatric, stroke-biomarker, hepatitis C and diabetic-foot studies); NONE administers resistin as an intervention. Zero relevant human trials recorded.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28608237 ↗2017Reported benefit

Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)MaleIntracerebroventricular and intraperitoneal10 ug/kg body weight for the intraperitoneal route; intrace…

Model: Middle cerebral artery occlusion (45 min ischaemia followed by 24 h reperfusion), focal cerebral ischaemia/reperfusion

Resistin given by intracerebroventricular or intraperitoneal route reduced infarct volume and neurological deficits after MCAO, lowered PARP-1 cleavage and raised phospho-Akt, with improved balance and muscle strength at 14 days. Neuroprotection was partially reversed by wortmannin, implicating PI3…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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Resistin (recombinant adipokine peptide)