Vesicular melatonin efficiently downregulates sodium fluoride-induced rat hepato- and broncho-TNF-alpha, TGF-beta expressions, and associated oxidative injury: a comparative study of liposomal and nanoencapsulated forms.
RatChemical/toxinSwiss albinoMalen = 30 male rats in 6 groups of 5 for the main study; an additi…Intravenous (tail vein) for melatonin; NaF by oral gavage4.46 mg/kg body weight melatonin (free, liposomal or nanoen…2 hours after NaF exposure
Model: Acute sodium fluoride intoxication (48 mg/kg body weight, single oral gavage) causing hepatic and pulmonary oxidative injury
Vesicular melatonin given 2 h after NaF reversed the rise in ROS, lipid peroxidation, NADH oxidase activity, TNF-alpha and TGF-beta, and restored antioxidant enzymes, membrane potential and microviscosity in liver and lung. Nanoencapsulated melatonin was most effective, followed by charge-specific…
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