Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema.
RatSpinal cord injuryContusionLong-EvansMale and femaleIntraperitoneal30 mg/kg10 min after spinal contusion
Model: Severe T9 contusion spinal cord injury using the New York University weight-drop device, 10 g rod from 50 mm height after T9 laminectomy
Methylprednisolone blocked the injury-induced rise in AQP4, increased Evans blue extravasation by about 80% and raised spinal water content, worsening oedema without any motor improvement at 24 h.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.