Ethyl pyruvate alleviates radiation-induced lung injury in mice.
MouseRadiationC57BL/6Male100 mg/kg
Model: Radiation-induced lung injury from a single thoracic irradiation of 16 Gy X-rays
Ethyl pyruvate reduced pulmonary inflammatory infiltration and HMGB1, IL-6, IL-1beta and GM-CSF at 4 weeks, and lowered collagen deposition with reduced TGF-beta1 and HMGB1 at 20 weeks after irradiation.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.