Cromolyn Sodium Attenuates Paraquat-Induced Lung Injury by Modulation of Proinflammatory Cytokines.
RatChemical/toxinWistarFemaleNebulised inhalation6 and 8 mg/kg/day nebulised; uninjured comparison group rec…From 1 week before paraquat administration to 2 weeks after
Model: Paraquat-induced lung injury by single oral dose of paraquat 40 mg/kg
Lung hydroxyproline and serum IL-1 beta, TNF-alpha and IL-8 were significantly lower in cromolyn-treated rats than in the paraquat group, with the best response at 8 mg/kg and supporting histology.
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