Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyMale and femaleAcute, early post-trauma
Model: Midline T9 contusion spinal cord injury at 150 kDyn (1 s dwell) or 200 kDyn, and unilateral T13 contusion at 100 kDyn
Contusion injury produced mechanical allodynia (males only in the 150 kDyn midline model) and thermal hyperalgesia, but the early post-trauma course of morphine did not significantly amplify chronic neuropathic pain in any model.
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