A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5.
RatSpinal cord injuryUnspecifiedSprague-DawleyMaleIntrathecal injection
Model: Acute spinal cord injury model in rats
PRDM5 was upregulated 2.212-fold at mRNA level and miR-182 and miR-7a fell by 44.6% and 39.3% after injury; intrathecal miR-182 and miR-7a suppressed PRDM5 and neuronal apoptosis and improved neurological function, with BBB score increased 2-fold.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.