THERAPY DOSSIER · th-909adae8a810

miR-182 and miR-7a

Other · MicroRNA mimics/inhibitors; no ChEMBL entity. ClinicalTrials.gov searched ('miR-182'): 0 hits.

Evidence & regulatory context

Mechanism: MicroRNA mimics/inhibitors; no ChEMBL entity. ClinicalTrials.gov searched ('miR-182'): 0 hits.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28552531 ↗2017Reported benefit

A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5.

RatSpinal cord injuryUnspecifiedSprague-DawleyMaleIntrathecal injection

Model: Acute spinal cord injury model in rats

PRDM5 was upregulated 2.212-fold at mRNA level and miR-182 and miR-7a fell by 44.6% and 39.3% after injury; intrathecal miR-182 and miR-7a suppressed PRDM5 and neuronal apoptosis and improved neurological function, with BBB score increased 2-fold.

Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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