Daily acute intermittent hypoxia improves breathing function with acute and chronic spinal injury via distinct mechanisms.
RatSpinal cord injuryHemisection / partialLewis (Study 1) and Sprague-Dawley (Study 2)Malen = Study 1: injured n=7, treated n=8, treated plus methysergid…Inhalational for the hypoxia protocol; intraperitoneal for methysergide or vehicle10 episodes of 5 min at 10.5% O2 separated by 5 min at 21%…Started 7 days post-injury in Study 1 and 7 weeks post-injury in Study 2
Model: Left C2 lateral spinal hemisection after C2 dorsal laminectomy, dura incised, micro-scalpel section plus aspiration
Daily acute intermittent hypoxia restored minute ventilation toward control at both 2 weeks (through increased breathing frequency, unaffected by methysergide) and 8 weeks post-injury (through increased tidal volume), but the 8-week benefit was abolished by methysergide.
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