THERAPY DOSSIER · th-152eef996d45

Daily acute intermittent hypoxia, with methysergide as a mechanistic serotonin receptor antagonist

Procedure · 5-HT2b antagonist; 5-HT1a partial agonist; 5-HT2c antagonist

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: 5-HT2b antagonist; 5-HT1a partial agonist; 5-HT2c antagonist
Target: CHEMBL1833 (5-HT2b), CHEMBL214 (5-HT1a), CHEMBL225 (5-HT2c)
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: 1962
Development stage: Not recorded
ChEMBL record: CHEMBL1065 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Deseril; Sansert; Methysergide maleate; Metisergida; NSC-759143
Note: Not recorded

Clinical trials 7

5 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05341466 ↗Injury indicationNAcompleted

Changes in Corticospinal Excitability and Motor Learning After Acute Intermittent Hypoxia

Incomplete Spinal Cord Injury

Enrolment: 56 · Results not recorded

NCT06520358 ↗Injury indicationNAcompleted

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Traumatic Brain Injury

Enrolment: 5 · Results not recorded

NCT03262766 ↗Injury indicationNAunknown

Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI

Spinal Cord Injuries

Enrolment: 80 · Results not recorded

NCT03922802 ↗Injury indicationNAcompleted

Locomotor Function Following AIH and Transcutaneous Electrical Spinal Cord Stimulation With Gait Therapy in SCI

Spinal Cord Injuries · Spinal Cord Diseases

Enrolment: 14 · Results not recorded

NCT02274116 ↗Injury indicationNAactive not recruiting

Repetitive Exposure of Intermittent Hypoxia to Enhance Walking Recovery in Persons With Chronic Spinal Cord Injury

Spinal Cord Injuries

Enrolment: 30 · Results not recorded

NCT03453697 ↗NAunknown

Effects of Acute Intermittent Hypoxia on Brain Function Imaging and Systemic Inflammation

Hypoxemia

Enrolment: 15 · Results not recorded

NCT05164705 ↗NAcompleted

Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia

Healthy Brain Perfusion

Enrolment: 33 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28549897 ↗2017Reported benefit

Daily acute intermittent hypoxia improves breathing function with acute and chronic spinal injury via distinct mechanisms.

RatSpinal cord injuryHemisection / partialLewis (Study 1) and Sprague-Dawley (Study 2)Malen = Study 1: injured n=7, treated n=8, treated plus methysergid…Inhalational for the hypoxia protocol; intraperitoneal for methysergide or vehicle10 episodes of 5 min at 10.5% O2 separated by 5 min at 21%…Started 7 days post-injury in Study 1 and 7 weeks post-injury in Study 2

Model: Left C2 lateral spinal hemisection after C2 dorsal laminectomy, dura incised, micro-scalpel section plus aspiration

Daily acute intermittent hypoxia restored minute ventilation toward control at both 2 weeks (through increased breathing frequency, unaffected by methysergide) and 8 weeks post-injury (through increased tidal volume), but the 8-week benefit was abolished by methysergide.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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