IL-18 cleavage triggers cardiac inflammation and fibrosis upon beta-adrenergic insult.
MouseChemical/toxinC57BL/6, with IL-18 and NLRP3 knockout linesMaleEarly after isoproterenol treatment
Model: Acute beta-adrenergic cardiac injury induced by a single subcutaneous dose of isoproterenol 5 mg/kg body weight
IL-18 neutralising antibodies selectively abated isoproterenol-induced chemokines, proinflammatory cytokines and adhesion molecules but not growth factors, and early blockade attenuated cardiac inflammation and fibrosis.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.