A Single-patient Clinical Trial of MAS825 in a Patient With XIAP Deficiency
X-linked Lymphoproliferative Syndrome Type 2 (XLP-2)
Enrolment: 1 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
X-linked Lymphoproliferative Syndrome Type 2 (XLP-2)
Enrolment: 1 · Results not recorded
Kidney Transplantation (Status Post)
Enrolment: 7 · Results not recorded
Coronary Heart Disease · Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Enrolment: 31 · Results not recorded
VEXAS Syndrome
Enrolment: 120 · Results not recorded
Crohn Disease
Enrolment: 5 · Results not recorded
Dermatitis, Atopic
Enrolment: 34 · Results not recorded
Dermatitis, Atopic
Enrolment: 38 · Results not recorded
Colitis, Ulcerative
Enrolment: 16 · Results not recorded
Colitis, Ulcerative
Enrolment: 16 · Results not recorded
Healthy Volunteers
Enrolment: 80 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute beta-adrenergic cardiac injury induced by a single subcutaneous dose of isoproterenol 5 mg/kg body weight
IL-18 neutralising antibodies selectively abated isoproterenol-induced chemokines, proinflammatory cytokines and adhesion molecules but not growth factors, and early blockade attenuated cardiac inflammation and fibrosis.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.