Early heparin administration after traumatic brain injury: Prolonged cognitive recovery associated with reduced cerebral edema and neutrophil sequestration.
MouseTBIControlled cortical impactCD1 from Charles RiverMalen = 44 animals in total: sham n=10, injured untreated n=11, hep…Subcutaneous75 U/kg or 225 U/kgFirst dose 2 h after injury
Model: Severe traumatic brain injury by controlled cortical impact through a left 4 mm craniotomy between bregma and lambda, 3 mm diameter impactor tip, impact velocity 6 m/s, cortical deformation 1.0 mm, over left parietotemporal cortex
Heparin 75 U/kg improved Garcia scores at all time points (24 h 16.0 plus or minus 1.0 versus 14.7 plus or minus 1.0), reduced brain water (77.3 plus or minus 0.6% versus 78.8 plus or minus 0.8%, p=0.04) and neutrophil sequestration (60.8 plus or minus 40.9 versus 124.2 plus or minus 44.1 per high-…
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