Effects of Heparin on Early Patency of Arteriovenous Fistula in Angioaccess Surgery in End-Stage Renal Disease
Arteriovenous Fistula
Enrolment: 150 · Results not recorded
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Drug · Antithrombin-III activator; inhibits coagulation by activating antithrombin III, which then binds factor X
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Arteriovenous Fistula
Enrolment: 150 · Results not recorded
Antiphospholipid Syndrome
Enrolment: 0 · Results not recorded
Coagulation Disorder
Enrolment: 16 · Results not recorded
Venous Thromboembolic Disease
Enrolment: 100 · Results not recorded
Heparin-induced Thrombocytopenia
Enrolment: 39 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Severe traumatic brain injury by controlled cortical impact through a left 4 mm craniotomy between bregma and lambda, 3 mm diameter impactor tip, impact velocity 6 m/s, cortical deformation 1.0 mm, over left parietotemporal cortex
Heparin 75 U/kg improved Garcia scores at all time points (24 h 16.0 plus or minus 1.0 versus 14.7 plus or minus 1.0), reduced brain water (77.3 plus or minus 0.6% versus 78.8 plus or minus 0.8%, p=0.04) and neutrophil sequestration (60.8 plus or minus 40.9 versus 124.2 plus or minus 44.1 per high-…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Controlled cortical impact through a 4 mm left parietotemporal craniotomy, 3 mm impactor tip, impact velocity 6 m/s, 1.0 mm cortical deformation
Both heparin doses reduced leukocyte rolling (70.4 to 37.2 and 29.6 cells per 100 micrometres per minute), cerebrovascular albumin leakage (44.3% to 33.3% and 30.1%) and ipsilateral brain water content. Only the 75 U/kg dose improved the Garcia Neurological Test at 24 and 48 hours, while 225 U/kg d…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: mouse ear-wound model used to assess homing of injected bone marrow-derived mononuclear cells
Heparin dose-dependently inhibited basal and SDF-1-induced migration, abrogated SDF-1-induced invasion (16 plus or minus 8 percent of control, P < 0.01) and reduced in vivo homing of injected cells in the mouse ear-wound model (69 plus or minus 10 percent of control, P < 0.05), without affecting ap…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.