Tendon stem/progenitor cells regulate inflammation in tendon healingJNK and STAT3 signaling.
RatOtherSprague-DawleyLocal delivery into the transected patellar tendon
Model: Full transection of the patellar tendon
CTGF delivery increased CD146-positive tendon stem/progenitor cells and enhanced healing, reduced iNOS-positive M1 macrophages and increased IL-10 at 2 days, sustained IL-10 with attenuated IL-6 at 1 week, and produced organised MMP-3 expression along reorienting collagen fibres with TIMP-3 express…
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