THERAPY DOSSIER · th-4b38c3776a51

Connective tissue growth factor (CTGF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28533328 ↗2017Reported benefit

Tendon stem/progenitor cells regulate inflammation in tendon healingJNK and STAT3 signaling.

RatOtherSprague-DawleyLocal delivery into the transected patellar tendon

Model: Full transection of the patellar tendon

CTGF delivery increased CD146-positive tendon stem/progenitor cells and enhanced healing, reduced iNOS-positive M1 macrophages and increased IL-10 at 2 days, sustained IL-10 with attenuated IL-6 at 1 week, and produced organised MMP-3 expression along reorienting collagen fibres with TIMP-3 express…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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