Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleIntravenous, tail vein0.01 mg/kg20 minutes before ischaemia
Model: Total brain ischaemia, with brains removed from anaesthetised rats and subjected to 120 minutes of ischaemia
Intravenous rotenone given 20 minutes before ischaemia increased resistance to calcium-induced pore opening and decreased reactive oxygen species production in mitochondria isolated from ischaemia-damaged cortex and cerebellum, and reduced infarct size in both regions. Added directly to normal cort…
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