THERAPY DOSSIER · th-d341ea0bd56f

Rotenone

Drug · ChEMBL name search returned ZERO records for 'rotenone' on two attempts (lower and title case), so no ChEMBL identity is asserted. ClinicalTrials.gov searched: 0 hits. Rotenone is a mitochondrial complex I inhibitor used as a research/toxicological tool, not a human therapeutic.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL name search returned ZERO records for 'rotenone' on two attempts (lower and title case), so no ChEMBL identity is asserted. ClinicalTrials.gov searched: 0 hits. Rotenone is a mitochondrial complex I inhibitor used as a research/toxicological tool, not a human therapeutic.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28527718 ↗2017Reported benefit

Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains.

RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleIntravenous, tail vein0.01 mg/kg20 minutes before ischaemia

Model: Total brain ischaemia, with brains removed from anaesthetised rats and subjected to 120 minutes of ischaemia

Intravenous rotenone given 20 minutes before ischaemia increased resistance to calcium-induced pore opening and decreased reactive oxygen species production in mitochondria isolated from ischaemia-damaged cortex and cerebellum, and reduced infarct size in both regions. Added directly to normal cort…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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