Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats.
RatSpinal cord injuryContusionSprague-DawleyMaleIntravenous injection100 micrograms/kg in 100 microlitres15 minutes and 24 hours after injury
Model: Acute contusion spinal cord injury after T10 laminectomy, weight dropped from a height of 8 cm onto a 0.3 cm diameter impounder on the exposed cord, under ketamine 80 mg/kg and xylazine 10 mg/kg anaesthesia
ENOblock significantly lowered serum neuron specific enolase and inflammatory cytokines and chemokines, altered metabolic factors and MMP expression in cord tissue, and reduced gliosis on immunohistochemistry.
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