Haptoglobin Reduces Inflammatory Cytokine INF-gamma and Facilitates Clot Formation in Acute Severe Burn Rat Model.
RatBurnScaldSprague-DawleyMalen = 30 rats in total across three groups, with 5 per group euth…IntraperitonealLow dose 4 mL (80 U)/kg with 16 mL/kg normal saline; high d…After the burn injury, exact interval not stated
Model: Full-thickness scald burn covering more than 30% of the dorsal skin surface under anaesthesia
Haptoglobin significantly reduced free haemoglobin at 24 hours and improved haematuria at the high dose, showed only a trend to lower interferon-gamma, produced no change in thrombin-antithrombin or plasmin-alpha2 plasmin inhibitor complexes, and increased clot firmness with shorter time to maximum…
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