THERAPY DOSSIER · th-cdfafe29593e

Haptoglobin

Biologic · ChEMBL not queried in this run (time budget); resolved=false reflects absence of a lookup, not a negative result. ClinicalTrials.gov searched: 76 raw hits, ALL are haptoglobin genotype/phenotype or zonulin (pre-haptoglobin 2) biomarker studies (HIV, COPD, delirium, IBS, wound healing); NONE administers haptoglobin as an intervention. Zero relevant human trials recorded.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL not queried in this run (time budget); resolved=false reflects absence of a lookup, not a negative result. ClinicalTrials.gov searched: 76 raw hits, ALL are haptoglobin genotype/phenotype or zonulin (pre-haptoglobin 2) biomarker studies (HIV, COPD, delirium, IBS, wound healing); NONE administers haptoglobin as an intervention. Zero relevant human trials recorded.
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28502961 ↗2017Mixed findings

Haptoglobin Reduces Inflammatory Cytokine INF-gamma and Facilitates Clot Formation in Acute Severe Burn Rat Model.

RatBurnScaldSprague-DawleyMalen = 30 rats in total across three groups, with 5 per group euth…IntraperitonealLow dose 4 mL (80 U)/kg with 16 mL/kg normal saline; high d…After the burn injury, exact interval not stated

Model: Full-thickness scald burn covering more than 30% of the dorsal skin surface under anaesthesia

Haptoglobin significantly reduced free haemoglobin at 24 hours and improved haematuria at the high dose, showed only a trend to lower interferon-gamma, produced no change in thrombin-antithrombin or plasmin-alpha2 plasmin inhibitor complexes, and increased clot firmness with shorter time to maximum…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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Haptoglobin