Interleukin-22 Prevents Microbial Dysbiosis and Promotes Intestinal Barrier Regeneration Following Acute Injury.
MouseBurnScaldn = Mortality was observed in 3 of 21 mice given ethanol and bu…Administered following the combined ethanol and burn injury
Model: Ethanol gavage (blood ethanol approximately 100 mg/dL) followed four hours later by a scald burn covering approximately 12.5% of total body surface area, under ketamine 80 mg/kg and xylazine 1.2 mg/kg anaesthesia
IL-22 restored crypt epithelial proliferation, raised antimicrobial peptide transcripts, eliminated the Enterobacteriaceae expansion and partially reduced hepatic and pulmonary inflammatory markers; protection was completely lost in intestinal epithelial STAT3 knockout mice.
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