PRECLINICAL PUBLICATION · 2017

The 5-HTReceptor Antagonist Ondansetron Attenuates Pancreatic Injury in Cerulein-Induced Acute Pancreatitis Model.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Ondansetron (5-HT3 receptor antagonist) and SCH527123 (CXCR2 antagonist), alongside serotonin-depleting tools p-chlorophenylalanine and 5,7-dihydroxytryptamine

PMID 28493078 ↗2017Reported benefit

The 5-HTReceptor Antagonist Ondansetron Attenuates Pancreatic Injury in Cerulein-Induced Acute Pancreatitis Model.

MouseChemical/toxinBALB/cMaleSubcutaneous3 mg/kg

Model: Cerulein-induced acute pancreatitis, induced by hourly injection of cerulein

Ondansetron significantly lowered plasma amylase, lipase and interleukin-6, attenuated histological inflammatory damage and reduced myeloperoxidase-positive neutrophil infiltration.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.