Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner.
MouseChemical/toxinC57Bl/6MaleInjection; specific route not stated
Model: Concanavalin A and alpha-galactosylceramide-induced acute immune-mediated liver injury
Mesenchymal stem cells reduced concanavalin A and alpha-galactosylceramide-mediated hepatitis, suppressed inflammatory natural killer T cell cytokines and cytotoxicity, and this protection was reversed by inhibition of indoleamine 2,3-dioxygenase or inducible nitric oxide synthase.
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