Rehabilitation Therapy vs Umbilical Cord Derived Mesenchymal Stem Cells Transplantation in Chronic Spinal Cord Injury
Spinal Cord Injury
Enrolment: 300 · Results not recorded
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Biologic
8 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injury
Enrolment: 300 · Results not recorded
Spinal Cord Injury
Enrolment: 40 · Results not recorded
Spinal Cord Injuries
Enrolment: 43 · Results not recorded
Acute Traumatic Spinal Cord Injury
Enrolment: 48 · Results not recorded
Spinal Cord Injury, Chronic
Enrolment: 10 · Results not recorded
Spinal Cord Injuries
Enrolment: 14 · Results not recorded
Spinal Cord Injury
Enrolment: 12 · Results not recorded
Spinal Cord Injury at C5-C7 Level
Enrolment not recorded · Results not recorded
Syringomyelia
Enrolment: 18 · Results not recorded
Brain Death
Enrolment: 20 · Results not recorded
14 studies reported at therapy level; 14 evidence entries itemised.
Model: Renal ischaemia-reperfusion (60 min clamping, contralateral nephrectomy)
Mesenchymal stem cells improved renal function and restored antioxidant balance after renal ischaemia-reperfusion.
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Model: Acute spinal cord injury
Infused mesenchymal stem cells altered the motor cortex gene expression signature at 3 days, and a set of behaviourally associated differentially expressed genes correlated with functional outcome, but the study did not itself establish a treatment effect size on function.
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Model: Concanavalin A and alpha-galactosylceramide-induced acute immune-mediated liver injury
Mesenchymal stem cells reduced concanavalin A and alpha-galactosylceramide-mediated hepatitis, suppressed inflammatory natural killer T cell cytokines and cytotoxicity, and this protection was reversed by inhibition of indoleamine 2,3-dioxygenase or inducible nitric oxide synthase.
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Model: Acute lung injury induced by intratracheal instillation of lipopolysaccharide
Mesenchymal stem cell treatment modulated pulmonary inflammation, decreased oxidative damage and reduced the release of neutrophil extracellular traps, with a significant increase in the survival curve of treated animals.
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Model: Sciatic nerve trunk crush injury
Nerves treated with mesenchymal stem cells showed better functional recovery and more pronounced regeneration than phosphate buffered saline controls. Fractional anisotropy and radial diffusivity returned to baseline about one week earlier in treated nerves (p = 0.045 and 0.035), and treated nerves…
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Model: Unilateral lung contusion alone or lung contusion followed by chronic restraint stress
Adding mesenchymal stem cells to lung contusion plus chronic stress increased bone marrow cellularity by 22%, significantly increased CFU-GEMM, BFU-E and CFU-E colony growth, reduced plasma granulocyte colony-stimulating factor and prevented prolonged progenitor mobilisation to peripheral blood.
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Model: Unilateral lung contusion induced by a percussive nail gun blast wave against a 12 mm metal plate, followed by haemorrhagic shock with mean arterial pressure held at 30 to 35 mmHg for 45 min and then reinfusion of shed blood
Lung Injury Score at 7 days was 0.8 (SD 0.4) after contusion alone, 3.7 (SD 0.81) after contusion plus haemorrhagic shock and 1.6 (SD 0.6) with mesenchymal stem cells (p less than 0.05 versus contusion plus shock), driven by lower oedema subscores. Peripheral regulatory T cells rose from 9.3 to 18.…
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Model: Full-thickness excisional skin wound
TSG-6 released from mesenchymal stem cells suppressed TNF-alpha release from activated macrophages and induced a shift to a low, anti-fibrotic TGF-beta1/TGF-beta3 ratio, improving wound healing and limiting fibrosis.
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Model: Acute lung injury induced by Escherichia coli lipopolysaccharide given intratracheally (2 mg/kg in 0.05 mL saline, pulmonary injury) or intraperitoneally (20 mg/kg in 0.5 mL saline, extrapulmonary injury), with controls receiving equivalent volumes of saline
Mesenchymal stem cells reduced lung elastance, alveolar collapse and inflammation at days 2 and 7 in both models, and reduced collagen deposition only in pulmonary acute lung injury, where matrix metalloproteinase-8 increased and tissue inhibitor of metalloproteinase-1 decreased
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Model: Bleomycin-induced lung injury from a single bolus intranasal instillation of bleomycin
Human mesenchymal stem cell xenotransplantation produced transient improvement in lung weight and tidal volume and persistent improvement in inspiratory duty cycle, inspiratory flow rate and inspiration to expiration ratio in SCID mice, with reduced Ashcroft scores, collagen deposition and inflamma…
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Model: Acute paraquat poisoning with lung injury induced by intraperitoneal paraquat 24 mg/kg body weight; in vitro rat type II pneumocyte L2 cells exposed to 0.5 mM paraquat
Mesenchymal stem cell transplantation 6 h after paraquat exposure reduced deterioration of liver and renal function, alleviated lung injury and prolonged survival, with coculture showing reduced paraquat accumulation and increased antioxidative gene expression in type II pneumocytes.
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Model: Spinal cord compression injury
Acute transplantation of mesenchymal stem cells into the compressed spinal cord reduced lesion volume by 31.6 per cent and improved posture, hindlimb flexion, sensory and foot-fault scores compared with untreated injured mice, for example 7.50 versus 15.83 foot-fault mistakes.
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Model: Corneal alkali burn using a 3 mm filter paper soaked in sodium hydroxide applied to the right eye
Subconjunctival mesenchymal stem cells accelerated corneal epithelial recovery, reduced neovascularisation and CD68-positive infiltration, and lowered MIP-1 alpha, tumour necrosis factor alpha and VEGF; MCP-1 was unchanged.
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Model: Surgical laceration and repair of the external anal sphincter
Direct injection of mesenchymal stem cells improved contractile function at 21 days versus controls, with earlier TGF-beta1 and lysyl oxidase expression, increased collagen deposition and engraftment. Intravenous delivery did not improve function, and cells did not alter the transient inflammatory…
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