Post-injury administration of a combination of memantine and 17beta-estradiol is protective in a rat model of traumatic brain injury.
RatTBIFluid percussionSprague-DawleyMaleIntravenous bolusAcutely after induction of injury
Model: Lateral fluid percussion traumatic brain injury
The memantine plus 17beta-estradiol combination increased neuronal survival, reduced neuronal degeneration in ipsilateral hippocampus and cortex, improved vestibulomotor deficits and modestly reduced anxiety.
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