Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats.
RatIschaemia-reperfusionRenalSprague-DawleyMalen = 40 rats randomised into four groupsGiven after shock wave lithotripsy and before nephrectomy
Model: Shock wave lithotripsy-induced renal ischaemia-reperfusion injury followed by nephrectomy
Both tadalafil and diltiazem reduced heat shock protein 70 immunostaining, tubular damage and peritubular fibrosis compared with untreated shock wave lithotripsy, with no significant difference between the two drugs.
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