THERAPY DOSSIER · th-3929569f741e

Diltiazem and tadalafil, assessed separately

Drug · BLOCKER of voltage-gated L-type calcium channel (direct interaction, disease efficacy).

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Evidence & regulatory context

Mechanism: BLOCKER of voltage-gated L-type calcium channel (direct interaction, disease efficacy).
Target: CHEMBL2095229 (voltage-gated L-type calcium channel)
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: 1982
Development stage: Not recorded
ChEMBL record: CHEMBL23 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Diltiazem; Diltiazem hydrochloride; Cardizem; Tildiem; Tiazac; Dilzem
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03472495 ↗PHASE4completed

Oral vs Intravenous Diltiazem for Rapid Atrial Fibrillation/Flutter Trial

Atrial Fibrillation and Flutter

Enrolment: 19 · Results not recorded

NCT00893100 ↗PHASE4completed

Evaluation of Pain Reduction After Hemorrhoidectomy With Use of Diltiazem Ointment 2%

Pain

Enrolment: 1 · Results not recorded

NCT04372082 ↗PHASE3withdrawn

Hydroxychloroquine and Diltiazem-Niclosamide Combination for Non-severe SARS-CoV2 Infection

Sars-CoV2

Enrolment: 0 · Results not recorded

NCT00422734 ↗PHASE3completed

Tadalafil 5 mg Once a Day Compared to Placebo in Improving Erectile Dysfunction and Sexual Quality of Life

Impotence

Enrolment: 342 · Results not recorded

NCT01261156 ↗PHASE1completed

Effects of Diltiazem, a Moderate CYP3A4/A5 Inhibitor, on PK/PD of E5555 in Healthy Subjects

Healthy Subjects

Enrolment: 24 · Results not recorded

NCT01211808 ↗PHASE1completed

Effect of Diltiazem on the Pharmacokinetics of BMS-914392 and on Heart Rate in Healthy Subjects

Atrial Fibrillation

Enrolment: 24 · Results not recorded

NCT02080780 ↗PHASE1completed

Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects

CLARITHROMYCIN/DILTIAZEM [VA Drug Interaction]

Enrolment: 24 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28471234 ↗2017Reported benefit

Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats.

RatIschaemia-reperfusionRenalSprague-DawleyMalen = 40 rats randomised into four groupsGiven after shock wave lithotripsy and before nephrectomy

Model: Shock wave lithotripsy-induced renal ischaemia-reperfusion injury followed by nephrectomy

Both tadalafil and diltiazem reduced heat shock protein 70 immunostaining, tubular damage and peritubular fibrosis compared with untreated shock wave lithotripsy, with no significant difference between the two drugs.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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