Neuregulin-1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury.
RatSpinal cord injuryCompressionFemale500 ng/day in mechanistic experiments and 1.5 micrograms/da…Immediate delivery after injury
Model: Clinically relevant model of severe compressive traumatic spinal cord injury
Neuregulin-1 promoted a neuroprotective inflammatory phenotype, reduced pro-inflammatory mediators and inhibitory chondroitin sulphate proteoglycans, and at 1.5 micrograms/day significantly improved tissue preservation and functional recovery.
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