Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury.
RatTBIPenetrating / ballisticSprague-DawleyMaleIntravenousLevetiracetam 12.5 to 100.0 mg/kg; gabapentin 1.25 to 25.0…Treatment began after injury; exact interval not stated
Model: Severe penetrating ballistic-like brain injury with post-traumatic nonconvulsive seizures monitored by continuous electroencephalography for 72 hours
Levetiracetam 25 to 100 mg/kg and gabapentin 6.25 to 25 mg/kg each reduced seizure frequency and duration, but the combination gave no additional benefit and isobolographic analysis did not reach additivity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.