Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation.
RatEndotoxin/LPSSprague-DawleyMalePretreatment beginning three days before lipopolysaccharide and d-galactosamine
Model: Acute liver injury induced by intraperitoneal injection of 8 micrograms lipopolysaccharide with 800 mg/kg d-galactosamine in sterile 0.9 per cent sodium chloride
Curcumin pretreatment reduced hepatic pathological damage, serum transaminases, malondialdehyde and tumour necrosis factor alpha, inhibited nuclear factor kappa B activation and dose-dependently upregulated nuclear Nrf2 and its antioxidant target genes.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.