Influence of daily oral prophylactic selenium treatment on the dibutyltin dichloride (DBTC)-induced pancreatitis in rats.
RatChemical/toxinLEW-1W inbred (Charles River)Malen = n = 6 per group, 3 groupsOral (per os)5 mg/kg body weightProphylactic, daily for 7 days before DBTC administration
Model: Dibutyltin dichloride (DBTC) 6 mg/kg body weight given as a single intravenous dose to induce experimental pancreatitis
Prophylactic oral sodium selenite significantly reduced serum malondialdehyde and bilirubin, lipase and transaminase activities and organ injury compared with DBTC alone, indicating reduced oxidative stress and a milder course of pancreatitis.
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