THERAPY DOSSIER · th-1a1cb4b29555

Sodium selenite (Na-selenite)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin · Radiation · Ischaemia-reperfusion · Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL112302 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Disodium selenite; Selenious acid disodium salt; NSC-347466; Sodium selenite anhydrous
Note: Not recorded

Clinical trials 9

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03081949 ↗PHASE4completed

Peripartum Cardiomyopathy in Nigeria (PEACE) - Oral Sodium Selenite 200 ug/day

Peripartum Cardiomyopathy

Enrolment: 100 · Results not recorded

NCT04201561 ↗PHASE3unknown

High Dose Inorganic Selenium for Preventing Chemotherapy Induced Peripheral Neuropathy (sodium selenite pentahydrate)

Chemotherapy-induced Peripheral Neuropathy · Recurrent Ovarian Carcinoma

Enrolment: 68 · Results not recorded

NCT02377635 ↗PHASE2completed

Selenium and Arsenic Pharmacodynamics (anhydrous selenite)

Arsenic Poisoning Chronic

Enrolment: 40 · Results not recorded

NCT01390506 ↗PHASE2withdrawn

Effect of High Dose Selenium on Inflammation and Neurological Outcome After Cardiac Arrest

Cardiac Arrest

Enrolment: 0 · Results not recorded

NCT01959438 ↗PHASE2unknown

Sodium Selenite as a Cytotoxic Agent in Advanced Carcinoma (Introselen)

Malignant Tumor

Enrolment: 32 · Results not recorded

NCT00207844 ↗PHASE2completed

Therapeutic administration of Selenium, as Selenite, in Septic Shock Patients

Septic Shock · Severe Sepsis

Enrolment: 60 · Results not recorded

NCT01155791 ↗PHASE1terminated

Phase I Study of Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate Cancer

Prostate Cancer

Enrolment: 2 · Results not recorded

NCT02066610 ↗Phase not recordedcompleted

Effect of Parenteral and Enteral Selenium Supplementation in Low Birth Weight Infants (sodium selenite)

Preterm Infants

Enrolment: 47 · Results not recorded

NCT02505295 ↗Phase not recordedcompleted

Evaluation of Selenium Supplementation in Ischemic Stroke Outcome

Ischemic Stroke

Enrolment: 44 · Results not recorded

Preclinical evidence 4

3 studies reported at therapy level; 4 evidence entries itemised.

PMID 28435430 ↗2017Reported benefit

Influence of daily oral prophylactic selenium treatment on the dibutyltin dichloride (DBTC)-induced pancreatitis in rats.

RatChemical/toxinLEW-1W inbred (Charles River)Malen = n = 6 per group, 3 groupsOral (per os)5 mg/kg body weightProphylactic, daily for 7 days before DBTC administration

Model: Dibutyltin dichloride (DBTC) 6 mg/kg body weight given as a single intravenous dose to induce experimental pancreatitis

Prophylactic oral sodium selenite significantly reduced serum malondialdehyde and bilirubin, lipase and transaminase activities and organ injury compared with DBTC alone, indicating reduced oxidative stress and a milder course of pancreatitis.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

PMID 28190183 ↗2017Mixed findings

Effect of Low-Dose Selenium Supplementation on the Genotoxicity, Tissue Injury and Survival of Mice Exposed to Acute Whole-Body Irradiation

MouseRadiationBALB/cMaleIntraperitoneal4 micrograms per kg body weightStarted 5 days before whole-body irradiation and continued after irradiation un…

Model: Acute whole-body irradiation at an absorbed dose of 8 Gy from a cobalt-60 source at 1 Gy/min

Low-dose sodium selenite did not protect against radiation-induced haematopoietic or gastrointestinal injury and did not improve 30-day survival, but it significantly prevented radiation-induced genotoxicity in peripheral leukocytes, differentially modulated GPx1, GPx2 and GPx4 mRNA in spleen and i…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 27192987 ↗2016Mixed findings

Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.

RatIschaemia-reperfusionOther / unspecifiedWistarMaleDietary (selenite) and intraperitoneal injection (ebselen)Diet supplemented with 1 ppm selenium as sodium selenite ve…Pretreatment before surgery; selenium diet for 5 weeks beforehand, ebselen inje…

Model: Cardiopulmonary bypass with 45 minutes of global ischaemia during deep hypothermic circulatory arrest at 16 degrees Celsius, followed by re-warming and reperfusion

Both selenite and ebselen suppressed ischaemia-reperfusion induced leukocytosis and the rise in plasma tissue damage markers, but neither prevented induction of the proinflammatory cytokines interleukin-6 and tumour necrosis factor alpha. Ebselen increased cardiac STAT3 phosphorylation and decrease…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

PMID 18209489 ↗2008

Selenium attenuates ROS-mediated apoptotic cell death of injured spinal cord through prevention of mitochondria dysfunction; in vitro and in vivo study

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

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