Memantine improves outcomes after repetitive traumatic brain injury.
MouseTBIClosed-head / concussionC57BL/6 (Jackson Laboratories)Malen = 95 mice total: repetitive mild TBI plus memantine n = 29, r…Intraperitoneal10 mg/kg in 0.2 mLWithin 1 hour after the last injury
Model: Repetitive mild closed head injury, 54 g metal bolt dropped from 71 cm onto the head under a guide tube centred over bregma, once daily for 4 consecutive days
Memantine reduced acute tau phosphorylation, glial activation and long-term potentiation deficits at one month and normalised NMDA receptor expression, but did not produce corresponding improvements in behavioural outcomes.
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