Erythropoietin protects against rhabdomyolysis-induced acute kidney injury by modulating macrophage polarization.
MouseCrushLimb / muscle crushC57BL/6JmaleIntraperitoneal500 IU/kg body weightFirst dose 30 min after glycerol injection
Model: Rhabdomyolysis-induced acute kidney injury by intramuscular injection of 50% glycerol 10 ml/kg into the hind limbs
EPO improved renal function and histology, reduced tubular apoptosis and pro-inflammatory cytokines, decreased macrophage recruitment and shifted macrophages towards an M2 phenotype via Jak2/STAT3/STAT6.
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