Glibenclamide, a diabetic drug, prevents acute radiation induced liver injury of mice via up-regulating intracellular ROS and subsequently activating Akt-NF-kappaB pathway.
MouseRadiationBALB/cmalen = n=5 mice per group per time point for histology, serum chem…Intraperitoneal10 mg/kg in vivo; 100 micromolar in vitro1 h before irradiation (pre-treatment)
Model: Single 30 Gy hepatic irradiation from a cobalt-60 source at 1 Gy/min with lead shielding confining the beam to the liver
Glibenclamide before hepatic irradiation reduced hepatocellular oedema and serum ALP and lowered TUNEL positivity from 78.3 plus or minus 9.5 per cent to 47.3 plus or minus 9.1 per cent, while conversely increasing radiation-induced apoptosis in HepG-2 hepatoma cells in vitro.
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