The Safety and Effectiveness of Glibenclamide in the Treatment of Aneurysm Subarachnoid Hemorrhage(aSAH): a Randomized Controlled Clinical Study
Subarachnoid Hemorrhage
Enrolment: 110 · Results not recorded
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Drug · Sulfonylurea receptor 1, Kir6.2 blocker (BLOCKER; direct interaction)
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Subarachnoid Hemorrhage
Enrolment: 110 · Results not recorded
Acute Spinal Cord Injury
Enrolment: 3 · Results not recorded
Acute Spinal Cord Injury
Enrolment: 12 · Results not recorded
Gestational Diabetes Mellitus
Enrolment: 73 · Results not recorded
Multiple Sclerosis · Neuropathic Pain
Enrolment: 10 · Results not recorded
Hemodynamics of Cranial Arteries · Headache · Cerebral Blood Flow
Enrolment: 15 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: Unilateral cervical spinal cord contusion at C7 by weight drop (10 g released from 30 mm) onto the left lateral cord after laminectomy, producing haemorrhagic contusion and high mortality
Both drugs reduced capillary fragmentation and progressive haemorrhagic necrosis acutely and prevented death, whereas vehicle mortality was very high. At 6 weeks modified BBB scores were similar, but glibenclamide gave significantly better rearing, rotarod, grip strength and tissue sparing than ril…
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Model: Cervical hemicontusion spinal cord injury
Glibenclamide reduced post-traumatic intraspinal haemorrhage and improved function after dorsolateral (but not dorsomedial) cervical injury, replicating prior findings.
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Model: 8-minute asphyxial cardiac arrest with cardiopulmonary resuscitation, producing global ischaemic brain injury
Glibenclamide improved neurological deficit scores (median 51 versus 46, p less than 0.01) and quantitative EEG recovery (0.77 +/- 0.06 versus 0.63 +/- 0.04, p less than 0.001), with a trend to better 72-hour survival, and markedly reduced hippocampal NLRP3 and caspase-1 activation.
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Model: Single 30 Gy hepatic irradiation from a cobalt-60 source at 1 Gy/min with lead shielding confining the beam to the liver
Glibenclamide before hepatic irradiation reduced hepatocellular oedema and serum ALP and lowered TUNEL positivity from 78.3 plus or minus 9.5 per cent to 47.3 plus or minus 9.1 per cent, while conversely increasing radiation-induced apoptosis in HepG-2 hepatoma cells in vitro.
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Model: Parietal craniotomy followed by controlled cortical impact injury
Glibenclamide reduced brain water content (80.47 versus 80.83 percent) and contusion volume at all time points, for example 172.53 versus 299.20 cubic millimetres at 24 h, but did not alter acute physiological parameters or beam-walking performance.
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Model: Unilateral left blunt impact to the cervical spinal cord at C7 after C7 laminectomy, using a 1.01 g guide tube impactor with a 1.55 mm tip angled 5 degrees medially, driven by a 10 g weight dropped 25 mm at a velocity of 0.7 m/s, producing ipsilateral but not contralateral primary haemorrhage
Glibenclamide started 5 minutes after injury essentially abolished 24 h lesion expansion (1.2-fold versus 2.3-fold by MRI and 1.1-fold versus 2.2-fold by histology) and significantly improved unilateral BBB scores (ipsilateral median 9 versus 0, contralateral 12 versus 2, both P less than 0.001).
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