Short- and long-term effects of zinc treatment on lacrimal gland histopathology and tear functions tests in radioiodine-administered rats.
RatRadiationWistarFemalen = 40 rats in total, 20 per group; half of each group sacrific…Oral gastric gavage10 mg/kg zinc sulfate in 1 mL physiological salineGiven alongside the single 3 mCi dose of 131I and continued for 7 days
Model: Single oral dose of 3 mCi radioiodine (131I) causing lacrimal gland damage
At week 1 the zinc group had greater mean tear production than the radioiodine group (3.30 plus or minus 1.34 mm versus 2.10 plus or minus 1.07 mm, p=0.004) and lower corneal fluorescein staining scores (5.45 plus or minus 2.06 versus 7.85 plus or minus 1.90 points, p=0.001). By week 8 the differen…
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