Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Wound · Radiation
- Reported indication
- Zinc deficiency and dietary zinc supplementation (zinc sulfate; zinc acetate also for Wilson disease maintenance)
- First approval
- 1987
- Development stage
- Approved supplement; acute critical-illness/COVID adjunct use unproven
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- Zinc sulfate; Zinc sulphate; Zinc sulfate monohydrate; Zincosol; White vitriol
- Note
- Not recorded
Clinical trials 5
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Influence Of Early Antioxidant Supplements (Se, Zn, Vitamins C/B1/E) On Clinical Evolution And Organ Function In Critically Ill Cardiac Surgery, Major Trauma And Subarachnoid Haemorrhage Patients
Critically Ill Patients · Cardiac Surgery · Trauma · Subarachnoid Hemorrhage
Enrolment: 200 · Results not recorded
Efficacy and Tolerability of Nicotinamide Plus Cream (with Zinc PCA) for Moderate Acne Vulgaris in Indonesia
Acne Vulgaris
Enrolment: 125 · Results not recorded
Does Zinc Supplementation Enhance the Clinical Efficacy of Chloroquine/Hydroxychloroquine in Treatment of COVID-19?
COVID
Enrolment: 191 · Results not recorded
Prophylaxis for Healthcare Professionals Using Hydroxychloroquine Plus Vitamins C, D and Zinc During COVID-19
Pneumonitis · Coronavirus Infection
Enrolment: 80 · Results not recorded
Circadian Variation of Urinary Copper Excretion in Wilson Disease Patients Treated With Chelators or Zinc Salts
Wilson Disease
Enrolment: 30 · Results not recorded
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
RatWoundFemale
Model: Experimental trauma with formation of early granulation tissue
Zinc did not alter the rate of collagen synthesis, but specific activity of collagen was lower in zinc treated rats on days 4 and 5, which the authors interpret as reduced collagen breakdown.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
RatWoundFemaleIntramuscular injectionOne arm treated postoperatively only; a second arm treated both preoperatively…
Model: Surgical trauma with subcutaneously implanted polyvinyl sponges to assess granulation tissue formation
Zinc given only postoperatively had no effect, whereas zinc given preoperatively as well as postoperatively increased collagen content on the fourth postoperative day but not later.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
RatRadiationWistarFemalen = 40 rats in total, 20 per group; half of each group sacrific…Oral gastric gavage10 mg/kg zinc sulfate in 1 mL physiological salineGiven alongside the single 3 mCi dose of 131I and continued for 7 days
Model: Single oral dose of 3 mCi radioiodine (131I) causing lacrimal gland damage
At week 1 the zinc group had greater mean tear production than the radioiodine group (3.30 plus or minus 1.34 mm versus 2.10 plus or minus 1.07 mm, p=0.004) and lower corneal fluorescein staining scores (5.45 plus or minus 2.06 versus 7.85 plus or minus 1.90 points, p=0.001). By week 8 the differen…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.