Acute ethanol exposure-induced autophagy-mediated cardiac injury via activation of the ROS-JNK-Bcl-2 pathway.
MouseChemical/toxinC57BL/6 and metallothionein-overexpressing (MT-TG) transgenic miceMale
Model: Acute binge ethanol exposure causing cardiomyocyte autophagy and apoptosis (alcoholic cardiac injury)
Acute ethanol exposure increased LC3-II and LC3-II positive puncta and promoted cardiomyocyte apoptosis in vivo and in vitro. Pharmacological inhibition of autophagic flux significantly reduced ethanol-induced cardiomyocyte apoptosis and heart injury. N-acetyl cysteine and SP600125 each reduced eth…
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