Pioglitazone treatment following spinal cord injury maintains acute mitochondrial integrity and increases chronic tissue sparing and functional recovery.
MouseSpinal cord injuryContusionC57BL/6malen = 64 mice total; sham n=7; acute mitochondrial cohort n=27 in…Intraperitoneal10 mg/kg, dissolved in DMSO at 3 mg/mlFirst injection at 15 min or at 3 h after injury
Model: Severe mid-thoracic contusion spinal cord injury, T9 laminectomy and Infinite Horizons impactor at 75 kdyn (achieved force approximately 78 kdyn); sham was laminectomy only
Pioglitazone preserved acute mitochondrial respiration near sham levels and, with 5 days of daily dosing, improved locomotor recovery and increased grey and white matter sparing, but did not reduce chronic microglial and macrophage IBA-1 immunoreactivity.
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