Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity.
MouseRadiationC3H/HeN, C57BL/6, B6C3F1 and CD2F1malen = Groups of 24 mice for survival and optimisation studies; 16…Subcutaneous, at the nape of the neck0.17 mg/kg (5 micrograms per mouse) optimal; escalation tes…First dose 24 h after irradiation in the main studies; time-optimisation arms s…
Model: Bilateral total-body irradiation from a cobalt-60 gamma source at a midline dose rate of 0.6 Gy/min; LD70/30 doses of 7.8-8.0 Gy (C3H/HeN), 8.0-8.2 Gy (C57BL/6), 8.5 Gy (B6C3F1) and 9.25 Gy (CD2F1); sublethal haematology doses of 6.5 Gy and 7 Gy
Three daily subcutaneous doses of 0.17 mg/kg filgrastim starting 24 h after lethal total-body irradiation raised 30-day survival in all four strains and accelerated haematopoietic recovery, whereas the conventional 16-day schedule failed to improve survival in three of four strains and efficacy was…
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