Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS.
MouseChemical/toxinCD-1MaleTopical to the ear; addition to culture medium in vitro2.0 mg per ear of extract, acid mixture or eupatorin; in vi…Applied topically 30 min after TPA; in vitro cells pre-treated for 2 h before l…
Model: Acute ear oedema induced by topical application of 2.5 micrograms 12-O-tetradecanoylphorbol-13-acetate in 25 microlitres acetone to the right ear, acetone alone to the left ear; separately J774A.1 macrophages stimulated with 1 microgram/ml lipopolysaccharide for 24 h
At 2 mg per ear the extract, the acid mixture and eupatorin inhibited TPA-induced ear oedema by 60.55 plus or minus 1.8%, 57.2 plus or minus 1.1% and 56.4 plus or minus 1.4% respectively, compared with 64.5 plus or minus 1.4% for indomethacin. At 25 micrograms/ml the extract reduced TNF-alpha 2.0-f…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.