THERAPY DOSSIER · th-9800f57cf536

Standardised dichloromethane extract of Salvia connivens (DESC), standardised on ursolic acid at 126 mg/g; active fractions were an acid mixture (ursolic acid 47.69%, oleanolic acid 41.18%, dihydroursolic acid 11.13%) and eupatorin

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28347190 ↗2017Reported benefit

Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS.

MouseChemical/toxinCD-1MaleTopical to the ear; addition to culture medium in vitro2.0 mg per ear of extract, acid mixture or eupatorin; in vi…Applied topically 30 min after TPA; in vitro cells pre-treated for 2 h before l…

Model: Acute ear oedema induced by topical application of 2.5 micrograms 12-O-tetradecanoylphorbol-13-acetate in 25 microlitres acetone to the right ear, acetone alone to the left ear; separately J774A.1 macrophages stimulated with 1 microgram/ml lipopolysaccharide for 24 h

At 2 mg per ear the extract, the acid mixture and eupatorin inhibited TPA-induced ear oedema by 60.55 plus or minus 1.8%, 57.2 plus or minus 1.1% and 56.4 plus or minus 1.4% respectively, compared with 64.5 plus or minus 1.4% for indomethacin. At 25 micrograms/ml the extract reduced TNF-alpha 2.0-f…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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