Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse.
MouseRadiationBALB/c25 mg/kg dailyAdministered 1 h after the acute irradiation or after each fractionated irradia…
Model: Acute whole-body irradiation with 5 Gy, or fractionated exposure with 0.5 Gy daily for 10 days to a total dose of 5 Gy
Acute 5 Gy irradiation caused deficits in contextual learning and memory and in novel object recognition and impaired subgranular zone neurogenesis, while fractionated exposure caused less loss of newly generated neurons and no behavioural deficit. Ursolic acid at 25 mg/kg daily for 30 days greatly…
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